Lignans with Anti-Hepatitis B Virus Activities from Phyllanthus niruri L.
Article first published online: 1 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 26, Issue 7, pages 964–968, July 2012
How to Cite
Wei, W., Li, X., Wang, K., Zheng, Z. and Zhou, M. (2012), Lignans with Anti-Hepatitis B Virus Activities from Phyllanthus niruri L. Phytother. Res., 26: 964–968. doi: 10.1002/ptr.3663
- Issue published online: 5 JUL 2012
- Article first published online: 1 DEC 2011
- Manuscript Accepted: 29 AUG 2011
- Manuscript Revised: 7 AUG 2011
- Manuscript Received: 7 MAY 2011
- National Natural Science Foundation of China. Grant Numbers: 30660216, 81060261
- Phyllantus niruri L.;
- nirtetralin B;
One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis. These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC50 values for HBsAg of 9.5 µm (nirtetralin A), 16.7 µm (nirtetralin B) and 97.2 µm (nirtetralin), IC50 values for HBeAg of 17.4 µm (nirtetralin A), 69.3 µm (nirtetralin B) and 232.0 µm (nirtetralin), respectively. Copyright © 2011 John Wiley & Sons, Ltd.