Protective Effects of Paeoniflorin Against Corticosterone-induced Neurotoxicity in PC12 Cells
Article first published online: 1 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 26, Issue 7, pages 969–973, July 2012
How to Cite
Mao, Q.-Q., Zhong, X.-M., Qiu, F.-M., Li, Z.-Y. and Huang, Z. (2012), Protective Effects of Paeoniflorin Against Corticosterone-induced Neurotoxicity in PC12 Cells. Phytother. Res., 26: 969–973. doi: 10.1002/ptr.3673
- Issue published online: 5 JUL 2012
- Article first published online: 1 DEC 2011
- Manuscript Accepted: 1 SEP 2011
- Manuscript Revised: 29 AUG 2011
- Manuscript Received: 1 JUN 2011
- PC12 cells;
Neuroprotection has been proposed as one of the acting mechanisms of antidepressants. Paeoniflorin, a monoterpene glycoside, has been reported to display antidepressant-like effects in animal models of behavioural despair. The present study aimed to examine the protective effect of paeoniflorin treatment on corticosterone-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. Paeoniflorin was shown to elevate cell viability, decrease levels of intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) in corticosterone-treated PC12 cells. Paeoniflorin also reversed the reduced nerve growth factor (NGF) mRNA level caused by corticosterone in PC12 cells. The results suggest that paeoniflorin exerts a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, at least in part, via the inhibition of oxidative stress and the up-regulation of NGF expression. This neuroprotective effect may be one of the action pathways that accounts for the in vivo antidepressant activity of paeoniflorin. Copyright © 2011 John Wiley & Sons, Ltd.