Protective Effects of Astaxanthin from Paracoccus carotinifaciens on Murine Gastric Ulcer Models
Article first published online: 14 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 26, Issue 8, pages 1126–1132, August 2012
How to Cite
Murata, K., Oyagi, A., Takahira, D., Tsuruma, K., Shimazawa, M., Ishibashi, T. and Hara, H. (2012), Protective Effects of Astaxanthin from Paracoccus carotinifaciens on Murine Gastric Ulcer Models. Phytother. Res., 26: 1126–1132. doi: 10.1002/ptr.3681
- Issue published online: 22 JUL 2012
- Article first published online: 14 DEC 2011
- Manuscript Accepted: 18 SEP 2011
- Manuscript Revised: 9 SEP 2011
- Manuscript Received: 1 AUG 2011
- antioxidant effect;
- gastric ulcer;
- Paracoccus carotinifaciens
The purpose of this study was to investigate the effect of astaxanthin extracted from Paracoccus carotinifaciens on gastric mucosal damage in murine gastric ulcer models. Mice were pretreated with astaxanthin for 1 h before ulcer induction. Gastric ulcers were induced in mice by oral administration of hydrochloride (HCl)/ethanol or acidified aspirin. The effect of astaxanthin on lipid peroxidation in murine stomach homogenates was also evaluated by measuring the level of thiobarbituric acid reactive substance (TBARS). The free radical scavenging activities of astaxanthin were also measured by electron spin resonance (ESR) measurements. Astaxanthin significantly decreased the extent of HCl/ethanol- and acidified aspirin-induced gastric ulcers. Astaxanthin also decreased the level of TBARS. The ESR measurement showed that astaxanthin had radical scavenging activities against the 1,1-diphenyl-2-picrylhydrazyl radical and the superoxide anion radical. These results suggest that astaxanthin has antioxidant properties and exerts a protective effect against ulcer formation in murine models. Copyright © 2011 John Wiley & Sons, Ltd.