Research Article

Differential Effects of Chlorogenic Acid on Various Immunological Parameters Relevant to Rheumatoid Arthritis

  1. Prashant Singh Chauhan1,*,
  2. Naresh Kumar Satti2,
  3. Punita Sharma2,
  4. Vijay Kumar Sharma2,
  5. Krishan Avtar Suri2,
  6. Sarang Bani1

Article first published online: 19 DEC 2011

DOI: 10.1002/ptr.3684

Issue

Phytotherapy Research

Phytotherapy Research

Volume 26, Issue 8, pages 1156–1165, August 2012

Additional Information

How to Cite

Chauhan, P. S., Satti, N. K., Sharma, P., Sharma, V. K., Suri, K. A. and Bani, S. (2012), Differential Effects of Chlorogenic Acid on Various Immunological Parameters Relevant to Rheumatoid Arthritis. Phytother. Res., 26: 1156–1165. doi: 10.1002/ptr.3684

Author Information

  1. 1

    Cell Biology Laboratory, Division of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir -180001, India

  2. 2

    Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir -180001, India

*Prashant Singh Chauhan, Cell Biology Laboratory, Division of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir-180001, India.
E-mail: prashant.rrl@gmail.com

Publication History

  1. Issue published online: 22 JUL 2012
  2. Article first published online: 19 DEC 2011
  3. Manuscript Accepted: 18 SEP 2011
  4. Manuscript Revised: 3 SEP 2011
  5. Manuscript Received: 27 NOV 2010

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Keywords:

  • Chlorogenic acid;
  • T cells;
  • cytokines;
  • co-stimulatory molecules

Despite chlorogenic acid (CGA) being widely present in nature, particularly in the human diet, there is very little information regarding its pharmacological activities. The present investigation was carried out to investigate the antiarthritic activities of this compound in adjuvant induced-arthritis in male Wistar rats, and to explore the underlying mechanisms of actions in view of immunological responses. We observed that CGA effectively controlled the total (CD3) and differentiated (CD4 and CD8) T cells count at the dose of 40 mg/kg. We also assessed the effect on co-stimulatory molecules (CD28, CD80/86) and found that CGA efficiently suppressed CD80/86 but failed to bring any changes in the CD28 count, whereas ibuprofen (standard drug) resulted in highly significant inhibition of both. We next examined the effect on CD4+ T cells specific Th1/Th2 cytokines by flow cytometry and observed that CGA suppressed the Th1 cytokines in a highly significant manner but elevated Th2 cytokines with dose dependence. Results of the present investigation suggest that CGA is a potent antiarthritic agent. Copyright © 2011 John Wiley & Sons, Ltd.

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