Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats
Article first published online: 30 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 26, Issue 7, pages 1088–1091, July 2012
How to Cite
Ćebović, T. and Maksimović, Z. (2012), Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. Phytother. Res., 26: 1088–1091. doi: 10.1002/ptr.3703
- Issue published online: 5 JUL 2012
- Article first published online: 30 DEC 2011
- Manuscript Accepted: 7 OCT 2011
- Manuscript Revised: 6 OCT 2011
- Manuscript Received: 22 SEP 2011
- Ministry of Education and Science, Republic of Serbia. Grant Number: 173021
- Filipendula hexapetala;
- methanol extract;
- hepatoprotective activity
The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright © 2011 John Wiley & Sons, Ltd.