Effect of Pomegranate Juice on Intestinal Transport and Pharmacokinetics of Nitrendipine in Rats
Article first published online: 25 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 8, pages 1240–1245, August 2012
How to Cite
Voruganti, S., Yamsani, S. K., Ravula, S. K., Gannu, R. and Yamsani, M. R. (2012), Effect of Pomegranate Juice on Intestinal Transport and Pharmacokinetics of Nitrendipine in Rats. Phytother. Res., 26: 1240–1245. doi: 10.1002/ptr.3704
- Issue published online: 22 JUL 2012
- Article first published online: 25 JAN 2012
- Manuscript Accepted: 7 OCT 2011
- Manuscript Revised: 1 OCT 2011
- Manuscript Received: 7 JUL 2011
- Pomegranate juice;
Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochromes (CYP), particularly CYP2C9 and CYP3A4. The purpose of this study was to investigate the effect of oral PJ on the pharmacokinetics of nitrendipine (10 mg/kg) in rats. The effect of PJ was also investigated on the absorption kinetics of nitrendipine in rats using a single-pass intestinal perfusion model. There was a significant increase in effective permeability, absorption rate constant and fraction of drug absorbed in the pretreated group when compared with the control group, probably due to inhibition of the P-glycoprotein-mediated efflux of the drug by PJ. In comparison with control, PJ treatment significantly increased the area under the concentration–time curve of oral nitrendipine. The peak plasma concentration of nitrendipine was also significantly increased by PJ. However, elimination half-life of nitrendipine was not altered significantly in both PJ co-administered and pretreated groups. These results suggest that PJ inhibits the intestinal metabolism of nitrendipine without inhibiting the hepatic metabolism in rats. Therefore, the concomitant use of PJ, as food supplement, and nitrendipine should be avoided, although further clinical studies need to be undertaken in order to confirm this finding. Copyright © 2012 John Wiley & Sons, Ltd.