Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L.
Article first published online: 4 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 8, pages 1178–1181, August 2012
How to Cite
Nguyen, M. T. T. and Nguyen, N. T. (2012), Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L. Phytother. Res., 26: 1178–1181. doi: 10.1002/ptr.3710
- Issue published online: 22 JUL 2012
- Article first published online: 4 JAN 2012
- Manuscript Accepted: 17 OCT 2011
- Manuscript Revised: 13 OCT 2011
- Manuscript Received: 29 JUN 2011
- Blumea balsamifera;
- xanthine oxidase inhibition
From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(−)-4′-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–4 and 6–8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC50 values ranging from 0.23 to 1.91 µ m, than that of a positive control allopurinol (IC50 2.50 µ m). Copyright © 2012 John Wiley & Sons, Ltd.