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Research Article
Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L.
Article first published online: 4 JAN 2012
DOI: 10.1002/ptr.3710
Copyright © 2012 John Wiley & Sons, Ltd.
Additional Information
How to Cite
Nguyen, M. T. T. and Nguyen, N. T. (2012), Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L. Phytother. Res., 26: 1178–1181. doi: 10.1002/ptr.3710
Publication History
- Issue published online: 22 JUL 2012
- Article first published online: 4 JAN 2012
- Manuscript Accepted: 17 OCT 2011
- Manuscript Revised: 13 OCT 2011
- Manuscript Received: 29 JUN 2011
Keywords:
- Blumea balsamifera;
- Asteraceae;
- (2R,3S)-(−)-4′-O-methyldihydroquercetin;
- xanthine oxidase inhibition
From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(−)-4′-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–4 and 6–8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC50 values ranging from 0.23 to 1.91 µ m, than that of a positive control allopurinol (IC50 2.50 µ m). Copyright © 2012 John Wiley & Sons, Ltd.