Xanthine Oxidase Inhibitors from Vietnamese Blumea balsamifera L.


Dr Mai Thanh Thi Nguyen, Faculty of Chemistry, University of Science, Vietnam National University, HoChiMinh City, Vietnam.

E-mail: nttmai@hcmus.edu.vn


From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(−)-4′-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–4 and 6–8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC50 values ranging from 0.23 to 1.91 µ m, than that of a positive control allopurinol (IC50 2.50 µ m). Copyright © 2012 John Wiley & Sons, Ltd.