• Aconitum C20-diterpenoid alkaloid;
  • hematopoietic stem/progenitor cells (HSPCs);
  • structure–activity relationship (SAR)

The pharmacological activity of Aconitum alkaloids depends on their fundamental structure. While C19-norditerpenoid alkaloids present significant toxicity to the central nervous system, C20-diterpenoid alkaloids have reduced toxicities. However, there is little information regarding the precise pharmacological properties of C20-diterpenoid alkaloids. C20-diterpenoid alkaloid derivatives have explicit structure–activity relationships targeting various tumor cells, which depend on the C11-substrate. However, the present study showed that C6-derivatives additively or synergistically sustained proliferation of CD34+ hematopoietic stem/progenitor cells derived from the placental/umbilical cord blood. It revealed that identical structures belonging to C20-diterpenoid alkaloids surprisingly have opposing proliferative effects depending on the derivatization sites (C6 versus C11). Copyright © 2012 John Wiley & Sons, Ltd.