Inhibitory Effect of Ethanol Extract of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease via Regulating β-Secretase Activity

Authors

  • Young-Jung Lee,

    1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    3. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Dong-Young Choi,

    1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    3. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Sang Bae Han,

    1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    3. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Young Hee Kim,

    1. R&D Center, Bioland Ltd, Cheonan-Si, Chungnam, Korea
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  • Ki Ho Kim,

    1. R&D Center, Bioland Ltd, Cheonan-Si, Chungnam, Korea
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  • Bang Yeon Hwang,

    1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    3. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Jong-Koo Kang,

    1. College of Veterinary Medicine and Research Institute of Veterinary Medicine (RIVM), Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Beom Jun Lee,

    1. College of Veterinary Medicine and Research Institute of Veterinary Medicine (RIVM), Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Ki-Won Oh,

    1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    3. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
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  • Jin Tae Hong

    Corresponding author
    1. Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, Korea
    2. CBITRC, Chungbuk National University, Cheongju, Chungbuk, Korea
    • College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Korea
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Jin Tae Hong, College of Pharmacology, Chungbuk National University, 12, Gaeshin-dong, Heunduk-gu, Cheongju, Chungbuk 361–763, Korea.

E-mail: jinthong@chungbuk.ac.kr

Abstract

Alzheimer's disease (AD) is the most common form of dementia and is characterized by deposition of amyloid beta (Aβ) in the brain. The components of the herb Magnolia officinalis are known to have antiinflammatory, antioxidative and neuroprotective activities. In this study we investigated the effects of ethanol extract of M. officinalis on memory dysfunction and amyloidogenesis in a transgenic mouse model of AD. Oral pretreatment of ethanol extract of M. officinalis (10 mg/kg in 0.05% ethanol) into drinking water for 3 months inhibited memory impairment and Aβ deposition in the brain of Tg2576 mice. Ethanol extract of M. officinalis also decreased activity of β-secretase, cleaving Aβ from amyloid precursor protein (APP), and expression of β-site APP cleaving enzyme 1 (BACE1), APP and its product, C99. Our results showed that ethanol extract of M. officinalis effectively prevented memory impairment via down-regulating β-secretase activity. Copyright © 2012 John Wiley & Sons, Ltd.

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