Some of the results were presented at the Society of Experimental Biology (SEB) Annual Meeting at Marseille, France, 2008.
Lapacho Tea (Tabebuia impetiginosa) Extract Inhibits Pancreatic Lipase and Delays Postprandial Triglyceride Increase in Rats†
Version of Record online: 17 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 12, pages 1878–1883, December 2012
How to Cite
Kiage-Mokua, B. N., Roos, N. and Schrezenmeir, J. (2012), Lapacho Tea (Tabebuia impetiginosa) Extract Inhibits Pancreatic Lipase and Delays Postprandial Triglyceride Increase in Rats. Phytother. Res., 26: 1878–1883. doi: 10.1002/ptr.4659
- Issue online: 11 DEC 2012
- Version of Record online: 17 MAR 2012
- Manuscript Accepted: 5 FEB 2012
- Manuscript Revised: 31 JAN 2012
- Manuscript Received: 31 OCT 2011
- pancreatic lipase inhibitor;
- plant extracts;
- postprandial triglycerides;
- Tabebuia impetiginosa (lapacho tea);
Earlier work in our laboratory indicated that ethanolic extracts of Tabebuia impetiginosa, Arctium lappa L., Calendula officinalis, Helianthus annuus, Linum usitatissimum and L. propolis, inhibit pancreatic lipase in vitro. In a follow-up study we assessed their effects on plasma triglycerides in rats fed on a fatty meal. Extracts, orlistat or only ethanol were given orally to the rats together with the test meal and the rate of increase of postprandial triglycerides was assessed over 4 h. Clearing of the triglycerides from the blood compartment was abolished by inhibiting lipoprotein lipase with Triton WR-1339. Our results showed that out of all the extracts, the bark of Tabebuia impetiginosa led to a significant delay in the postprandial increase of plasma triglycerides. However, lapachol, which is contained in the bark of Tabebuia impetiginosa and soluble in ethanol, had no lipase inhibitory effect in vitro and hence this substance did not seem to mediate the pertinent effect. Copyright © 2012 John Wiley & Sons, Ltd.