Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata
Article first published online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 12, pages 1957–1960, December 2012
How to Cite
Favela-Hernández, J. M. J., García, A., Garza-González, E., Rivas-Galindo, V. M. and Camacho-Corona, M. R. (2012), Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata. Phytother. Res., 26: 1957–1960. doi: 10.1002/ptr.4660
- Issue published online: 11 DEC 2012
- Article first published online: 15 MAR 2012
- Manuscript Accepted: 5 FEB 2012
- Manuscript Revised: 3 FEB 2012
- Manuscript Received: 4 SEP 2011
- Larrea tridentate;
Three lignans and four flavonoids were isolated and characterized from Larrea tridentata and compounds were tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) and multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4-epi-larreatricin (2) was active against Enterobacter cloacae (MIC 12.5 µg/mL), as well as sensitive (MIC 50 µg/mL) and MDR strains of M. tuberculosis (MIC 25 µg/mL). 3′-Demethoxy-6-O-demethylisoguaiacin (3) displayed activity against sensitive and resistant S. aureus (MIC 25 µg/mL), Enterococcus faecalis (MIC 12.5 µg/mL), Escherichia coli (MIC 50 µg/mL), E. cloacae (MIC 12.5 µg/mL) and MDR strains of M. tuberculosis (MIC 12.5 µg/mL). 5,4′-Dihydroxy-3,7,8,3′-tetramethoxyflavone (4) and 5,4′-dihydroxy-3,7,8-trimethoxyflavone (5) were active against M. tuberculosis MDR strains having MIC values of 25 and 25–50 µg/mL, respectively, while 5,4′-dihydroxy-7-methoxyflavone (6) was active against S. aureus (MIC 50 µg/mL) and E. faecalis (MIC 50 µg/mL). We concluded that lignan 3 is the main compound responsible for the antibacterial activity of L. tridentata. Lignans 1 and 2 as well as flavonoid 6 contribute with some degree of antibacterial activity. On the other hand, compounds 1, 2, 3, 4 and 5 contributed to the antimycobacterial activity found in L. tridentata. Copyright © 2012 John Wiley & Sons, Ltd.