Negative Effects of Curcumin on Liver Injury Induced by Alcohol
Article first published online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 12, pages 1857–1863, December 2012
How to Cite
Zhao, H.-L., Song, C. H. and Chai, O. H. (2012), Negative Effects of Curcumin on Liver Injury Induced by Alcohol. Phytother. Res., 26: 1857–1863. doi: 10.1002/ptr.4664
- Issue published online: 11 DEC 2012
- Article first published online: 15 MAR 2012
- Manuscript Accepted: 10 FEB 2012
- Manuscript Revised: 8 FEB 2012
- Manuscript Received: 4 DEC 2011
- liver injury;
Curcumin is known for its antiinflammatory and antifibrotic properties in liver damage. However, the negative effects of curcumin on alcoholic liver damage are seldom reported. In this study, both advantageous and disadvantageous functions of curcumin on alcoholic liver injury were observed. In order to determine the effects of curcumin on liver fibrosis induced by alcohol, 5% ethanol and/or curcumin (1 × 10–3 or 1 × 10–4 m) were injected intravenously in mice. Hematoxylin-eosin staining was performed to determine the value of liver injury by optical density analyses. Liver histology was evaluated by an experienced hepatopathologist blinded to the type of treatment received by the animals. Ethanol accelerates serum levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), liver injury, production of tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β) and nuclear factor-kappa B (NF-κB) during 5% ethanol-induced liver injury. 1 × 10–3 m curcumin accelerates liver injury and liver cellular edema during only 5% ethanol-induced liver injury evolution, whereas 1 × 10–4 m curcumin does not lead to (or protect) alcoholic liver injury. Therefore, it is suggested that curcumin may have dual effects on alcoholic liver injury depending on its concentration. Copyright © 2012 John Wiley & Sons, Ltd.