Suppressive Effect of Flavonoids from Korean Citrus aurantium L. on the Expression of Inflammatory Mediators in L6 Skeletal Muscle Cells

Authors

  • Jin-A. Kim,

    1. Korea National Animal Research Resource Center, Korea National Animal Bio-Resource Bank, Gyeongsang National University, Jinju, Republic of Korea
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  • Hyeon-Soo Park,

    1. Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
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  • Sang-Rim Kang,

    1. Department of Biological Engineering, Kyongi University, suwon, Republic of Korea
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  • Kwang-Il Park,

    1. Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
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  • Do-Hoon Lee,

    1. Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
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  • ArulKumar Nagappan,

    1. Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
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  • Sung-Chul Shin,

    1. Department of Chemistry and Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea
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  • Won-Sup Lee,

    1. Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, Jinju, Republic of Korea
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  • Eun-Hee Kim,

    Corresponding author
    1. Department of Nursing Science, International University of Korea, Republic of Korea
    • Korea National Animal Research Resource Center, Korea National Animal Bio-Resource Bank, Gyeongsang National University, Jinju, Republic of Korea
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  • Gon-Sup Kim

    Corresponding author
    • Korea National Animal Research Resource Center, Korea National Animal Bio-Resource Bank, Gyeongsang National University, Jinju, Republic of Korea
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Professor Gon-Sup Kim, Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju, 660–701, Republic of Korea; Professor Eun Hee Kim, Department of Nursing Science, International University of Korea, Sangmoon, Jinju, 660–759, Republic of Korea.

E-mail: gonskim@gnu.ac.kr; iuknurse@nate.com

Abstract

Citrus fruits (Citrus aurantium L.) have long been used as a traditional herbal medicine. The benefits of the flavonoids found in Citrus aurantium L. include anti-inflammation, anti-cancer, anti-viral and anti-bacterial activities, and enhancement of the immune response. The study investigated the effect of the flavonoids isolated from Citrus aurantium L. native to Korea on the production of pro-inflammatory mediators by blocking signal transduction mediated by nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide (LPS)-induced L6 skeletal muscle cells. The flavonoids decreased the production of inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6 and tumor necrosis factor-alpha by suppressing NF-κB and MAPKs signal pathways in LPS-induced L6 skeletal muscle cells. These findings suggest that the flavonoids isolated from Korea Citrus aurantium L. might have anti-inflammatory effects that regulate the expression of inflammatory mediators in L6 skeletal muscle cells. Copyright © 2012 John Wiley & Sons, Ltd.

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