Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cells
Article first published online: 23 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 26, Issue 12, pages 1920–1926, December 2012
How to Cite
Dibwe, D. F., Awale, S., Kadota, S. and Tezuka, Y. (2012), Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC-1 Cells. Phytother. Res., 26: 1920–1926. doi: 10.1002/ptr.4672
- Issue published online: 11 DEC 2012
- Article first published online: 23 MAR 2012
- Manuscript Accepted: 15 FEB 2012
- Manuscript Revised: 9 FEB 2012
- Manuscript Received: 2 SEP 2011
- preferential cytotoxicity;
- Garcinia huillensis;
- pancreatic cancer
Screening of eight Congolese medicinal plants showed that the CHCl3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 µg/mL and 13.8 µg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 µg/mL) and Securidaca longepedunculata (PC50 = 23.4 µg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC50 = 4.46 µm and 3.77 µm, respectively). Copyright © 2012 John Wiley & Sons, Ltd.