Young-Mog Kim and Tae Hoon Kim equally contributed to this work.
Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis
Article first published online: 4 APR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 1, pages 148–151, January 2013
How to Cite
Eom, S.-H., Lee, M.-S., Lee, E.-W., Kim, Y.-M. and Kim, T. H. (2013), Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis. Phytother. Res., 27: 148–151. doi: 10.1002/ptr.4694
- Issue published online: 7 JAN 2013
- Article first published online: 4 APR 2012
- Manuscript Accepted: 9 MAR 2012
- Manuscript Revised: 7 MAR 2012
- Manuscript Received: 20 JUL 2011
- Ministry of Education, Science and Technology. Grant Number: 2010–0022783
- Eisenia bicyclis;
- pancreatic lipase inhibitor;
- fucofuroeckol A
Pancreatic lipase is a potential therapeutic target for the treatment of diet-induced obesity in humans. In an ongoing search for new pancreatic lipase inhibitors from natural sources, a methanolic extract of marine brown algae, Eisenia bicyclis, showed a significant inhibitory effect against pancreatic lipase. Bioassay-guided isolation of this methanolic extract using a pancreatic lipase inhibitory assay led to the isolation and identification of six known phlorotannins: eckol (1), fucofuroeckol A (2), 7-phloroeckol (3), dioxindehydroeckol (4), phlorofucofuroeckol A (5), and dieckol (6). The structures were established on the basis of nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Among the isolated phloroglucinol polymers, compounds 2 and 3 showed potent inhibitory effects on pancreatic lipase with IC50 values ranging from 37.2 ± 2.3 to 12.7 ± 1.0 μM, respectively. Copyright © 2012 John Wiley & Sons, Ltd.