This article was published online on 23 April 2012. Errors were subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected on 26 September.
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial†
Article first published online: 23 APR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 2, pages 218–226, February 2013
How to Cite
Suter, A., Saller, R., Riedi, E. and Heinrich, M. (2013), Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial. Phytother. Res., 27: 218–226. doi: 10.1002/ptr.4696
- Issue published online: 4 FEB 2013
- Article first published online: 23 APR 2012
- Manuscript Accepted: 16 MAR 2012
- Manuscript Revised: 15 MAR 2012
- Manuscript Received: 20 NOV 2011
- benign prostatic hyperplasia;
- sexual dysfunctions;
- clinical trial;
- saw palmetto;
- Serenoa repens
In elderly men, benign prostatic hyperplasia (BPH) is a major risk factor for sexual dysfunctions (SDys). Additionally, the standard treatments for BPH symptoms, alpha blockers and 5-alpha-reductase inhibitors, cause SDys themselves. Preparations from saw palmetto berries are an efficacious and well-tolerated symptomatic treatment for mild to moderate BPH and have traditionally been used to treat SDys. We conducted an open multicentric clinical pilot trial to investigate whether the saw palmetto berry preparation Prostasan® influenced BPH symptoms and SDys. Eighty-two patients participated in the 8-week trial, taking one capsule of 320 mg saw palmetto extract daily. At the end of the treatment, the International Prostate Symptom Score was reduced from 14.4 ± 4.7 to 6.9 ± 5.2 (p < 0.0001); SDys measured with the brief Sexual Function Inventory improved from 22.4 ± 7.2 to 31.4 ± 9.2 (p < 0.0001), and the Urolife BPH QoL-9 sex total improved from 137.3 ± 47.9 to 195.0 ± 56.3 (p < 0.0001). Investigators' and patients' assessments confirmed the good efficacy, and treatment was very well tolerated and accepted by the patients. Correlation analyses confirmed the relationship between improved BPH symptoms and reduced SDys. This was the first trial with saw palmetto to show improvement in BPH symptoms and SDys as well. [Corrections made here after initial online publication.] Copyright © 2012 John Wiley & Sons, Ltd.