Antihyperlipidemic Components of Cassia auriculata Aerial Parts: Identification Through In Vitro Studies
Article first published online: 18 APR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 1, pages 152–155, January 2013
How to Cite
Habtemariam, S. (2013), Antihyperlipidemic Components of Cassia auriculata Aerial Parts: Identification Through In Vitro Studies. Phytother. Res., 27: 152–155. doi: 10.1002/ptr.4711
- Issue published online: 7 JAN 2013
- Article first published online: 18 APR 2012
- Manuscript Revised: 26 MAR 2012
- Manuscript Accepted: 26 MAR 2012
- Manuscript Received: 5 FEB 2012
- University of Greenwich
- Cassia auriculata;
Cassia auriculata (Caesalpiniaceae) is a common Asian beverage and medicinal plant widely used in tradition medicine for diabetes, hyperlipidemia and various other disease conditions. Previous studies on crude extracts of C. auriculata have documented the scientific basis for some of its traditional medicinal uses. The present study investigates the antilipase activity of the ethanol extract of the aerial parts along with the previously isolated compounds (kaempferol-3-O-rutinoside, rutin, kaempferol, quercetin and luteolin). The crude extract displayed inhibitory activity against pancreatic lipase with IC50 of 6.0 ± 1.0 µg/mL. The most active antilipase compound was kaempferol-3-O-rutinoside with IC50 value (2.9 ± 0.50 μM) only about twice weaker than the standard antilipase drug, orlistat (IC50 = 1.45 ± 0.26 μM). Luteolin, quercetin and rutin were found to be weak pancreatic lipase inhibitors (IC50 over 100 μM), whereas kaempferol showed no activity up to 250 μM. The antihyperlipidemic effect of C. auriculata could be attributed to direct lipase inhibitory effect of the plant constituents. Copyright © 2012 John Wiley & Sons, Ltd.