Antiangiogenic Effects of P-Coumaric Acid in Human Endothelial Cells

Authors

  • Chang-Seok Kong,

    1. Department of Biomedical Science, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    2. Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
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    • These authors equally contributed to this work.
  • Chul-Ho Jeong,

    1. College of Pharmacy, Keimyung University, Daegu, Korea
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    • These authors equally contributed to this work.
  • Jae-Sun Choi,

    1. Department of Biomedical Science, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    2. Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
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  • Kil-Jung Kim,

    1. Department of Biomedical Science, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    2. Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
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  • Joo-Won Jeong

    Corresponding author
    1. Department of Biomedical Science, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    • Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
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Correspondence to: Joo-Won Jeong, Department of Anatomy and Neurobiology, School of Medicine, Kyung Hee University, Hoegidong 1, Dongdaemoongu, Seoul 130-701, Korea.

E-mail: jjeong@khu.ac.kr

Abstract

p-Coumaric acid, a hydroxy derivative of cinnamic acid, has been known to possess antioxidant and anticancer activities. Despite its potential contribution to chemopreventive effects, the mechanism by which p-coumaric acid exerts its antiangiogenic actions remains elusive. In this study, we revealed that p-coumaric acid inhibited the sprouting of endothelial cells in rat aortic rings and inhibited the tube formation and migration of endothelial cells. We observed that p-coumaric acid could downregulate mRNA expression levels of the key angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor. Also, we demonstrated that p-coumaric acid inhibited both the AKT and ERK signaling pathways, which are known to be crucial for angiogenesis. Using a mouse model, we also showed that p-coumaric acid effectively suppressed tumor growth in vivo by lowering hemoglobin contents. Collectively, these findings indicate that p-coumaric acid possesses potent anticancer properties due to the inhibition of angiogenesis in vivo. Copyright © 2012 John Wiley & Sons, Ltd.

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