These authors equally contributed to this work.
Antiangiogenic Effects of P-Coumaric Acid in Human Endothelial Cells
Article first published online: 14 MAY 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 3, pages 317–323, March 2013
How to Cite
Kong, C.-S., Jeong, C.-H., Choi, J.-S., Kim, K.-J. and Jeong, J.-W. (2013), Antiangiogenic Effects of P-Coumaric Acid in Human Endothelial Cells. Phytother. Res., 27: 317–323. doi: 10.1002/ptr.4718
- Issue published online: 6 MAR 2013
- Article first published online: 14 MAY 2012
- Manuscript Accepted: 13 APR 2012
- Manuscript Revised: 29 MAR 2012
- Manuscript Received: 22 FEB 2012
- cancer prevention;
- p-coumaric acid
p-Coumaric acid, a hydroxy derivative of cinnamic acid, has been known to possess antioxidant and anticancer activities. Despite its potential contribution to chemopreventive effects, the mechanism by which p-coumaric acid exerts its antiangiogenic actions remains elusive. In this study, we revealed that p-coumaric acid inhibited the sprouting of endothelial cells in rat aortic rings and inhibited the tube formation and migration of endothelial cells. We observed that p-coumaric acid could downregulate mRNA expression levels of the key angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor. Also, we demonstrated that p-coumaric acid inhibited both the AKT and ERK signaling pathways, which are known to be crucial for angiogenesis. Using a mouse model, we also showed that p-coumaric acid effectively suppressed tumor growth in vivo by lowering hemoglobin contents. Collectively, these findings indicate that p-coumaric acid possesses potent anticancer properties due to the inhibition of angiogenesis in vivo. Copyright © 2012 John Wiley & Sons, Ltd.