Antihyperglycemic Activity of Extracts from Boldoa purpurascens Leaves in Alloxan-Induced Diabetic Rats
Article first published online: 16 JUL 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 5, pages 721–724, May 2013
How to Cite
González Mosquera, D. M., Hernandez Ortega, Y., By, B., Vicet Muro, L., Saucedo Hernandez, Y., Grau Ábalos, R., Dehaen, W., Pieters, L. and Apers, S. (2013), Antihyperglycemic Activity of Extracts from Boldoa purpurascens Leaves in Alloxan-Induced Diabetic Rats. Phytother. Res., 27: 721–724. doi: 10.1002/ptr.4769
- Issue published online: 17 APR 2013
- Article first published online: 16 JUL 2012
- Manuscript Accepted: 4 JUN 2012
- Manuscript Revised: 20 APR 2012
- Manuscript Received: 5 JAN 2012
- Boldoa purpurascens;
- hypoglycemic activity;
In order to investigate the potential use of Boldoa purpurascens against diabetes, the antihyperglycemic effect of an ethanol extract obtained from its leaves was evaluated at doses of 50, 100 and 200 mg/kg in rats after induction of hyperglycemia by alloxan. Insulin 5 IU/kg was used as positive control and NaCl 0.9% as negative control. A similar experiment was performed with the aqueous extract used at doses of 50 and 100 mg/kg using metformin at a dose of 50mg/kg as positive control. Statistical analysis was carried using the Kruskal–Wallis test with an interval of trust of 99%. The ethanolic and aqueous extract of B. purpurascens showed a significant decrease of blood glucose levels 72 h after administration. Phytochemical analysis of the ethanol extract showed the presence of D-pinitol, a compound known for its hypoglycemic properties. In conclusion, ethanolic as well as aqueous extracts of B. purpurascens leaves show antihyperglycemic activity, possibly due to the presence of D-pinitol and flavonoids. Copyright © 2012 John Wiley & Sons, Ltd.