Effects of Penta-O-galloyl-β-D-glucose on Human Neutrophil Function: significant Down-Regulation of L-selectin Expression
Article first published online: 16 AUG 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 7, pages 986–992, July 2013
How to Cite
Kiss, A. K., Filipek, A., Żyżyńska-Granica, B. and Naruszewicz, M. (2013), Effects of Penta-O-galloyl-β-D-glucose on Human Neutrophil Function: significant Down-Regulation of L-selectin Expression. Phytother. Res., 27: 986–992. doi: 10.1002/ptr.4822
- Issue published online: 5 JUL 2013
- Article first published online: 16 AUG 2012
- Manuscript Accepted: 23 JUL 2012
- Manuscript Revised: 19 JUL 2012
- Manuscript Received: 20 MAR 2012
Penta-O-galloyl-β-D-glucose (PGG) occurrs in high concentrations in medicinal herbs such as Rhus chinensis, Paeonia suffruticosa, Acer truncatum and Terminalia chebula, which demonstrate anti-inflammatory activity. We investigated the effect of PGG on stimulated and non-stimulated neutrophils in processes which included reactive oxygen species generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), β2 integrin (CD11b) and L-selectin (CD62L) expression and apoptosis. In concentrations of 5 μM–20 μM, PGG demonstrated statistically significant inhibition of ROS generation, IL-8 secretion and β2 integrin expression in stimulated neutrophils. The inhibition of L-selectin expression by PGG resulted in prevention in neutrophils’ endothelial attachment. The result obtained may explain the anti-inflammatory activity of this compound and underline the contribution of PGG in the activity of PGG rich plant extracts. Copyright © 2012 John Wiley & Sons, Ltd.