Intrathecal -Gingerol Administration Alleviates Peripherally induced Neuropathic Pain in Male Sprague–Dawley Rats
Article first published online: 12 SEP 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 8, pages 1251–1254, August 2013
How to Cite
Gauthier, M.-L., Beaudry, F. and Vachon, P. (2013), Intrathecal -Gingerol Administration Alleviates Peripherally induced Neuropathic Pain in Male Sprague–Dawley Rats. Phytother. Res., 27: 1251–1254. doi: 10.1002/ptr.4837
- Issue published online: 22 JUL 2013
- Article first published online: 12 SEP 2012
- Manuscript Accepted: 15 AUG 2012
- Manuscript Revised: 12 JUN 2012
- Manuscript Received: 20 APR 2012
- National Sciences and Engineering Research Council of Canada. Grant Number: 386637–2010
- neuropathic pain;
-Gingerol, a structural analog of capsaicin, is an agonist of the transient receptor potential vanilloid 1 channel, which is known to have therapeutic properties for the treatment of pain and inflammation. The main objective of this study was to determine the central effect of -gingerol on neuropathic pain when injected intrathecally at the level of the lumbar spinal cord. -Gingerol distribution was evaluated following a 40 mg/kg intraperitoneal injection, and the brain-to-plasma and spinal cord-to-plasma ratios (0.73 and 1.7, respectively) suggest that -gingerol penetrates well the central nervous system of rats. Induction of pain was performed using the sciatic nerve ligation model on rats, and a 10-µg intrathecal injections of -gingerol was performed to evaluate its central effect. The results suggest a significant decrease of secondary mechanical allodynia after 30 min, 2 h and 4 h (p < 0.05, p < 0.01 and p < 0.001) and thermal hyperalgesia after 30 min, 2 h and 4 h (p < 0.05, p < 0.01 and p < 0.01). These promising results illustrate that -gingerol could alleviate neuropathic pain by acting centrally at the level of the spinal cord. Copyright © 2012 John Wiley & Sons, Ltd.