In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin-Resistant Staphylococcus aureus
Article first published online: 8 OCT 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 27, Issue 8, pages 1260–1264, August 2013
How to Cite
Eom, S.-H., Kim, D.-H., Lee, S.-H., Yoon, N.-Y., Kim, J. H., Kim, T. H., Chung, Y.-H., Kim, S.-B., Kim, Y.-M., Kim, H.-W., Lee, M.-S. and Kim, Y.-M. (2013), In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin-Resistant Staphylococcus aureus. Phytother. Res., 27: 1260–1264. doi: 10.1002/ptr.4851
- Issue published online: 22 JUL 2013
- Article first published online: 8 OCT 2012
- Manuscript Accepted: 2 SEP 2012
- Manuscript Revised: 1 SEP 2012
- Manuscript Received: 4 JUN 2012
- antibacterial activity;
- Eisenia bicyclis;
- methicillin-resistant Staphylococcus aureus;
Six phlorotannins, isolated from Eisenia bicyclis, were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol-A (PFF) exhibited the highest anti-MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β-lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti-MRSA activity of phlorotannins from E. bicyclis. The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA. Copyright © 2012 John Wiley & Sons, Ltd.