Ascorbigen Induces Dermal Papilla Cell Proliferation in Vitro, but Fails to Modulate Chemotherapy-Induced Alopecia in Vivo
Article first published online: 11 MAR 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 27, Issue 12, pages 1863–1867, December 2013
How to Cite
Wang, C.-H., Huang, H.-S., Dai, N.-T., Sheu, M.-J. and Chang, D.-M. (2013), Ascorbigen Induces Dermal Papilla Cell Proliferation in Vitro, but Fails to Modulate Chemotherapy-Induced Alopecia in Vivo. Phytother. Res., 27: 1863–1867. doi: 10.1002/ptr.4933
- Issue published online: 13 DEC 2013
- Article first published online: 11 MAR 2013
- Manuscript Accepted: 7 JAN 2013
- Manuscript Revised: 15 DEC 2012
- Manuscript Received: 12 FEB 2012
- Chi Mei Medical Center. Grant Number: CMNDMC10114
- dermal papilla;
- chemotherapy-induced alopecia
Ascorbigen (ABG) is the predominant indole-derived compound from Brassica vegetables. In this study, we attempted to evaluate the effects of ABG on hair growth. To this end, we examined the proliferation of isolated human dermal papilla (DP) cells and keratinocytes after incubation in various concentrations (0–1.25 mM) of ABG. Furthermore, hair shaft regrowth was monitored in a mouse model of chemotherapy-induced alopecia (CIA), and hematoxylin and eosin staining was performed for histological analyses. We found that 1.25 mM ABG induced a 1.2-fold increase in the growth of DP cells, but not keratinocytes. However, ABG did not exert significant protective effects against CIA in the mouse model. These findings suggest that ABG may not be able to counteract CIA and that further investigation of the therapeutic potential of ABG in disease models is required. Copyright © 2013 John Wiley & Sons, Ltd.