Anti-depressant Effects of Aqueous Extract from Acanthopanax senticosus in Mice

Authors

  • Liji Jin,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
    • Liji Jin and Feifei Wu equally contributed to this work.
  • Feifei Wu,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
    • Liji Jin and Feifei Wu equally contributed to this work.
  • Xiaoyu Li,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
  • Huaqiang Li,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
  • Chong Du,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
  • Qi Jiang,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    Search for more papers by this author
  • Jiansong You,

    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    3. Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian, P. R. China
    Search for more papers by this author
  • Shuying Li,

    1. Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian, P. R. China
    Search for more papers by this author
  • Yongping Xu

    Corresponding author
    1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, P. R. China
    2. Ministry of Education Center for Food Safety of Animal Origin, Dalian University of Technology, Dalian, P. R. China
    3. Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian, P. R. China
    4. State Key Laboratories of Fine Chemicals, Dalian University of Technology, Dalian, P. R. China
    • Correspondence to: Prof. Yongping Xu, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian 116024, P. R. China.

      E-mail: biohqff@163.com

    Search for more papers by this author

Abstract

In this paper, the anti-depressant effects of Acanthopanax senticosus extract (ASE) were studied using animal models of depression including the forced swimming and tail suspension tests. The anti-depressive mechanism of ASE was explored by monitoring the levels of monoamine neurotransmitters including 5-hydroxytrylamine (5-HT), norepinephrine (NE), and dopamine (DA), as well as cAMP response element-binding (CREB) protein expression in the whole brain of mice following the tail suspension test. Our results showed that intragastric administration of ASE at a dose of 2000 mg/kg for seven days significantly reduced the duration of immobility in both the forced swimming test and the tail suspension test. These results indicate that ASE possesses antidepressant-like properties. Pre-treatment with 2000 mg/kg of ASE for seven days significantly elevated the levels of 5-HT, NE, and DA in the whole brain of mice. Moreover, ASE at doses of 1000 and 2000 mg/kg significantly up-regulated the level of CREB protein. Taken together, these findings suggest that the anti-depressive mechanism of ASE may be mediated via the central monoaminergic neurotransmitter system and CREB protein expression. Therefore, administration of ASE may be beneficial for patients with depressive disorders. Copyright © 2013 John Wiley & Sons, Ltd.

Ancillary