The work performed by the first two authors is considered equivalent.
Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview
Article first published online: 19 FEB 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 27, Issue 12, pages 1745–1755, December 2013
How to Cite
Zhou, J., Ouedraogo, M., Qu, F. and Duez, P. (2013), Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview. Phytother. Res., 27: 1745–1755. doi: 10.1002/ptr.4942
- Issue published online: 13 DEC 2013
- Article first published online: 19 FEB 2013
- Manuscript Accepted: 9 JAN 2013
- Manuscript Revised: 2 JAN 2013
- Manuscript Received: 12 OCT 2012
- Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era. Grant Number: 223154
- International Science & Technology Cooperation Program of Zhejiang Province. Grant Number: 2012C24017
- Grant of Education Department of Zhejiang Province. Grant Number: Y20122335
- Young Scientist Grant of Zhejiang Gongshang University. Grant Number: QY11-20
- Chinese herbal medicine;
- aristolochic acids;
- pyrrolizidine alkaloids
In the last decades, cases of poisoning due to herbal medicines have occurred in many countries; Chinese herbal medicines (CHMs) are occasionally involved. The experience gained from traditional use is efficient to detect immediate or near-immediate relationship between administration and toxic effects but is quite unlikely to detect medium- to long-term toxicities; thorough investigations of herbal medicines (toxicity assessments, active pharmacovigilance) appear then essential for their safe use. Genotoxicity is an especially insidious toxicity that may result in carcinoma development years after exposure; it can arise from multiple compounds, with or without metabolic activation. The present work reviews traditional CHMs and phytochemicals that have been shown to present a genotoxic hazard. Copyright © 2013 John Wiley & Sons, Ltd.