Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview

Authors

  • Jue Zhou,

    1. College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, China
    Search for more papers by this author
    • The work performed by the first two authors is considered equivalent.

  • Moustapha Ouedraogo,

    1. Laboratory of Pharmacology and Toxicology, Health Sciences Faculty, University of Ouagadougou, Ouagadougou 03, Burkina Faso
    2. Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), Brussels, Belgium
    Search for more papers by this author
    • The work performed by the first two authors is considered equivalent.

  • Fan Qu,

    1. Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Search for more papers by this author
  • Pierre Duez

    Corresponding author
    1. Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), Brussels, Belgium
    2. Department of Therapeutical Chemistry and Pharmacognosy, Université de Mons (UMONS), Mons, Belgium
    • Correspondence to: Pierre Duez, Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), CP 205-9, B-1050 Brussels, Belgium.

      E-mail: pduez@ulb.ac.be

    Search for more papers by this author

Abstract

In the last decades, cases of poisoning due to herbal medicines have occurred in many countries; Chinese herbal medicines (CHMs) are occasionally involved. The experience gained from traditional use is efficient to detect immediate or near-immediate relationship between administration and toxic effects but is quite unlikely to detect medium- to long-term toxicities; thorough investigations of herbal medicines (toxicity assessments, active pharmacovigilance) appear then essential for their safe use. Genotoxicity is an especially insidious toxicity that may result in carcinoma development years after exposure; it can arise from multiple compounds, with or without metabolic activation. The present work reviews traditional CHMs and phytochemicals that have been shown to present a genotoxic hazard. Copyright © 2013 John Wiley & Sons, Ltd.

Ancillary