A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis
Article first published online: 21 MAR 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 28, Issue 1, pages 9–21, January 2014
How to Cite
Zhang, X., Hong, Y.-L., Xu, D.-S., Feng, Y., Zhao, L.-J., Ruan, K.-F. and Yang, X.-J. (2014), A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis. Phytother. Res., 28: 9–21. doi: 10.1002/ptr.4960
- Issue published online: 7 JAN 2014
- Article first published online: 21 MAR 2013
- Manuscript Accepted: 4 FEB 2013
- Manuscript Revised: 5 JAN 2013
- Manuscript Received: 9 JUL 2012
- amyotrophic lateral sclerosis;
- herbal medicine;
- active ingredients;
- experiment research
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease worldwide, leading to progressive muscle atrophy and paralysis. The limited success of conventional treatment for ALS has prompted investigations into complementary and alternative therapies. Herbal remedies provide good prospects of ALS prevention and treatment, with advantages such as multiple targets, multiple links, and few side effects. Studies in vitro and in vivo have shown that herbs have a great potential for treatment of ALS, with therapeutic effects against oxidative stress, excitatory amino acid toxicity, neuroinflammation, and calcium cytotoxicity. Active monomers or ingredients extracted from herbs are considered promising candidates for ALS. Therefore, we review recent experimental research on monomers and compounds isolated from herbal remedies for preventing and treating ALS. Copyright © 2013 John Wiley & Sons, Ltd.