A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis

Authors

  • Xue Zhang,

    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
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  • Yan-Long Hong,

    Corresponding author
    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
    • Correspondence to: Yan-Long Hong, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and De-Sheng Xu, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

      E-mail: hfuir@163.com; xudes1953@126.com

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  • De-Sheng Xu,

    Corresponding author
    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    • Correspondence to: Yan-Long Hong, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and De-Sheng Xu, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

      E-mail: hfuir@163.com; xudes1953@126.com

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  • Yi Feng,

    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
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  • Li-Jie Zhao,

    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
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  • Ke-Feng Ruan,

    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
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  • Xiu-Juan Yang

    1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2. Engineering Research Center of Modern Preparation Technology of Zhangjiang, Shanghai, China
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Abstract

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease worldwide, leading to progressive muscle atrophy and paralysis. The limited success of conventional treatment for ALS has prompted investigations into complementary and alternative therapies. Herbal remedies provide good prospects of ALS prevention and treatment, with advantages such as multiple targets, multiple links, and few side effects. Studies in vitro and in vivo have shown that herbs have a great potential for treatment of ALS, with therapeutic effects against oxidative stress, excitatory amino acid toxicity, neuroinflammation, and calcium cytotoxicity. Active monomers or ingredients extracted from herbs are considered promising candidates for ALS. Therefore, we review recent experimental research on monomers and compounds isolated from herbal remedies for preventing and treating ALS. Copyright © 2013 John Wiley & Sons, Ltd.

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