Fucoidan Prevents High-Fat Diet-Induced Obesity in Animals by Suppression of Fat Accumulation
Article first published online: 11 APR 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 28, Issue 1, pages 137–143, January 2014
How to Cite
Kim, M.-J., Jeon, J. and Lee, J.-S. (2014), Fucoidan Prevents High-Fat Diet-Induced Obesity in Animals by Suppression of Fat Accumulation. Phytother. Res., 28: 137–143. doi: 10.1002/ptr.4965
- Issue published online: 7 JAN 2014
- Article first published online: 11 APR 2013
- Manuscript Revised: 12 FEB 2013
- Manuscript Accepted: 12 FEB 2013
- Manuscript Received: 25 JUL 2011
- fat accumulation;
This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5 weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD + FUCO 1%) group and HFD containing 2% fucoidan (HFD + FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor γ, adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity. Copyright © 2013 John Wiley & Sons, Ltd.