Both KW and GG significantly contributed to writing this review.
Animal Studies on Medicinal Herbs: Predictability, Dose Conversion and Potential Value
Article first published online: 4 APR 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 28, Issue 1, pages 22–27, January 2014
How to Cite
Wojcikowski, K. and Gobe, G. (2014), Animal Studies on Medicinal Herbs: Predictability, Dose Conversion and Potential Value. Phytother. Res., 28: 22–27. doi: 10.1002/ptr.4966
- Issue published online: 7 JAN 2014
- Article first published online: 4 APR 2013
- Manuscript Accepted: 13 FEB 2013
- Manuscript Revised: 8 FEB 2013
- Manuscript Received: 6 JAN 2013
- medicinal herbs;
- dose translation;
- allometric scaling;
Animal studies testing medicinal herbs are often misinterpreted by both translational researchers and clinicians due to a lack of information regarding their predictability, human dose equivalent and potential value. The most common mistake is to design or translate an animal study on a milligram per kilogram basis. This can lead to underestimation of the toxicity and/or overestimation of the amount needed for human therapy. Instead, allometric scaling, which involves body surface area, should be used. While the differences in the pharmacokinetic and pharmacodynamic phases between species will inevitably lead to some degree of error in extrapolation of results regardless of the conversion method used, correct design and interpretation of animal studies can provide information that is not able to be provided by in vitro studies, computer modeling or even traditional use. Copyright © 2013 John Wiley & Sons, Ltd.