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Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects

Authors

  • Sedigheh Asgary,

    Corresponding author
    1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of medical Sciences, Isfahan, Iran
    • Correspondence to: Sedigheh Asgary, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of medical Sciences, Isfahan, Iran.

      E-mail: sasgary@yahoo.com

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  • Amirhossein Sahebkar,

    1. Biotechnology Research Center and School of Pharmacy, Mashhad, University of Medical Sciences, Mashhad, Iran
    2. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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  • Mohammad Reza Afshani,

    1. Department of Cardiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
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  • Mahtab Keshvari,

    1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of medical Sciences, Isfahan, Iran
    2. Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
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  • Shaghayegh Haghjooyjavanmard,

    1. Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
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  • Mahmoud Rafieian-Kopaei

    1. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
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Abstract

Pomegranate (Punica granatum L.) juice (PJ) contains different types of antioxidants and bioactive polyphenols and has been reported to promote cardiovascular health through several mechanisms. The present study aimed to examine the effects of 2-week intake of fresh PJ on blood pressure, flow-mediated dilatation (FMD), serum lipid profile and concentrations of inflammatory and endothelial function biomarkers. Twenty-one hypertensive patients (aged 30–67 years) were recruited into the trial and assigned to receive either PJ (150 ml/day in a single occasion between lunch and dinner; n = 11) or the same amount of water (n = 10) for a period of 2 weeks. Systolic (SBP) and diastolic (DBP) pressures together with FMD and serum concentrations of lipid profile parameters, apolipoproteins A and B, intracellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule 1 (VCAM-1), E-selectin, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured at baseline and at the end of trial. PJ consumption was associated with significant reductions in SBP (p = 0.002) and DBP (p = 0.038) but not FMD (p > 0.05). Serum levels of VCAM-1 (p = 0.008) were significantly reduced by PJ while those of E-selectin were elevated (p = 0.039). However, no significant effect was observed from PJ on serum levels of ICAM-1, hs-CRP, lipid profile parameters, apolipoproteins and IL-6 in any of the study groups (p > 0.05). Consumption of PJ for 2 weeks has effective hypotensive effects, and may improve endothelial function by decreasing serum concentrations of VCAM-1. These findings suggest PJ as a beneficial cardioprotective supplement for hypertensive subjects. Copyright © 2013 John Wiley & Sons, Ltd.

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