Furanodiene Presents Synergistic Anti-proliferative Activity With Paclitaxel Via Altering Cell Cycle and Integrin Signaling in 95-D Lung Cancer Cells
Article first published online: 3 APR 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Volume 28, Issue 2, pages 296–299, February 2014
How to Cite
Xu, W.-S., Dang, Y.-Y., Chen, X.-P., Lu, J.-J. and Wang, Y.-T. (2014), Furanodiene Presents Synergistic Anti-proliferative Activity With Paclitaxel Via Altering Cell Cycle and Integrin Signaling in 95-D Lung Cancer Cells. Phytother. Res., 28: 296–299. doi: 10.1002/ptr.4984
- Issue published online: 4 FEB 2014
- Article first published online: 3 APR 2013
- Manuscript Accepted: 5 MAR 2013
- Manuscript Revised: 26 FEB 2013
- Manuscript Received: 31 JAN 2013
- lung cancer;
- cell cycle;
- integrin β4
Furanodiene (FUR) is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anti-proliferative activities in several cancer cell lines. Recently, we found that the combined treatment of FUR with paclitaxel (TAX) showed synergetic anti-proliferative activities in 95-D lung cancer cells. Herein, we showed that FUR reduced the cell numbers distributed in mitosis phase induced by TAX while increased those in G1 phase. The protein levels of cyclin D1, cyclin B1, CDK6 and c-Myc were all down-regulated in the group of combined treatment. The dramatically down-regulated expression of integrin β4, focal adhesion kinase and paxillin might partially contribute to the synergic effect. Though FUR alone obviously induced endoplasmic reticulum stress, this signaling pathway may not contribute to the synergetic anti-proliferative effect as the protein expression of CHOP and BIP was similar in FUR alone and combined treatment group. Copyright © 2013 John Wiley & Sons, Ltd.