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Quinolone Alkaloids from Fructus Euodiae Show Activity Against Methicillin-Resistant Staphylococcus aureus

Authors

  • Xiaobei Pan,

    1. School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK
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  • S. W. Annie Bligh,

    1. School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK
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  • Eileen Smith

    Corresponding author
    1. School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK
    • Correspondence to: Eileen Smith, School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK.

      E-mail: Eileen.Smith@londonmet.ac.uk

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Abstract

Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8–128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections. Copyright © 2013 John Wiley & Sons, Ltd.

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