Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial

Authors

  • Yunes Panahi,

    1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Search for more papers by this author
  • Ali-Reza Rahimnia,

    Corresponding author
    1. Orthopedics Department, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
    2. Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
    • Correspondence to: Ali-Reza Rahimnia, MD, Orthopedics Department, Baqiyatallah University of Medical Sciences, P.O. Box: 19945-581, Tehran, Iran; Amirhossein Sahebkar, Pharm.D, PhD, Biotechnology Research Center, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran.

      E-mails: alireza_rahimnia@yahoo.com (Ali-Reza Rahimnia); sahebkara@mums.ac.ir; amir_saheb2000@yahoo.com (Amirhossein Sahebkar)

    Search for more papers by this author
  • Mojtaba Sharafi,

    1. Orthopedics Department, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
    2. Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Search for more papers by this author
  • Gholamhossein Alishiri,

    1. Internal Medicine Department, Faculty of medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Search for more papers by this author
  • Amin Saburi,

    1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Search for more papers by this author
  • Amirhossein Sahebkar

    Corresponding author
    1. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    2. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    • Correspondence to: Ali-Reza Rahimnia, MD, Orthopedics Department, Baqiyatallah University of Medical Sciences, P.O. Box: 19945-581, Tehran, Iran; Amirhossein Sahebkar, Pharm.D, PhD, Biotechnology Research Center, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran.

      E-mails: alireza_rahimnia@yahoo.com (Ali-Reza Rahimnia); sahebkara@mums.ac.ir; amir_saheb2000@yahoo.com (Amirhossein Sahebkar)

    Search for more papers by this author

Abstract

Treatment of osteoarthritis (OA) is challenging owing to the inefficacy and long-term adverse events of currently available medications including non-steroidal anti-inflammatory drugs. Curcuminoids are polyphenolic phytochemicals with established anti-inflammatory properties and protective effects on chondrocytes. The aim of this study is to investigate the clinical efficacy of curcuminoids in patients suffering from knee OA. A pilot randomized double-blind placebo-control parallel-group clinical trial was conducted among patients with mild-to-moderate knee OA. Patients were assigned to curcuminoids (1500 mg/day in 3 divided doses; n = 19) or matched placebo (n = 21) for 6 weeks. Efficacy measures were changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analogue scale (VAS) and Lequesne's pain functional index (LPFI) scores during the study. There was no significant difference in age, gender, body mass index, and VAS, WOMAC and LPFI scores between the study groups at baseline (p > 0.05). Treatment with curcuminoids was associated with significantly greater reductions in WOMAC (p = 0.001), VAS (p < 0.001) and LPFI (p = 0.013) scores compared with placebo. With respect to WOMAC subscales, there were significant improvements in the pain and physical function scores (p < 0.001) but not stiffness score (p > 0.05). There was no considerable adverse effect in both groups. To conclude, curcuminoids represent an effective and safe alternative treatment for OA. Copyright © 2014 John Wiley & Sons, Ltd.

Ancillary