Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum)
Article first published online: 30 JUL 2001
Copyright © 2001 John Wiley & Sons, Ltd.
Volume 15, Issue 5, pages 441–443, August 2001
How to Cite
Ju, Y., Still, C. C., Sacalis, J. N., Li, J. and Ho, C.-T. (2001), Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum). Phytother. Res., 15: 441–443. doi: 10.1002/ptr.686
- Issue published online: 30 JUL 2001
- Article first published online: 30 JUL 2001
- Manuscript Accepted: 10 FEB 2000
- Manuscript Revised: 23 JUN 1999
- Manuscript Received: 30 APR 1999
- Chinese National Natural Science Foundation, Tsinghua University
- US Department of Agriculture
- New Jersey Agricultural Experiment Station. Grant Number: 12172
- Zanthoxylum americanum;
Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC50 of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm). Copyright © 2001 John Wiley & Sons, Ltd.