Research Article

Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

  1. P. Stanely Mainzen Prince,
  2. Venugopal P. Menon*

Article first published online: 8 MAY 2001

DOI: 10.1002/ptr.707

Issue

Phytotherapy Research

Phytotherapy Research

Volume 15, Issue 3, pages 213–218, May 2001

Additional Information

How to Cite

Stanely Mainzen Prince, P. and Menon, V. P. (2001), Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytotherapy Research, 15: 213–218. doi: 10.1002/ptr.707

Author Information

  1. Department of Biochemistry, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India

*Department of Biochemistry, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India

Publication History

  1. Issue published online: 8 MAY 2001
  2. Article first published online: 8 MAY 2001
  3. Manuscript Accepted: 10 DEC 1999
  4. Manuscript Received: 1 MAR 1999

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Keywords:

  • Tinospora cordifolia;
  • aqueous extract;
  • alloxan diabetes;
  • antioxidant

Abstract

Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight. The effect of TCREt was more effective than glibenclamide. Thus our study shows that TCREt exhibits antioxidant action in alloxan diabetes. Copyright © 2001 John Wiley & Sons, Ltd.

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