Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama)
Article first published online: 15 MAY 2002
Copyright © 2002 John Wiley & Sons, Ltd.
Volume 16, Issue 3, pages 223–226, May 2002
How to Cite
da Silva, A. L., Bardini, S., Nunes, D. S. and Elisabetsky, E. (2002), Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama). Phytother. Res., 16: 223–226. doi: 10.1002/ptr.825
- Issue published online: 15 MAY 2002
- Article first published online: 15 MAY 2002
- Manuscript Accepted: 11 JAN 2001
- Manuscript Received: 7 JAN 2001
- FAPERGS. Grant Number: 98/1610-3
- Ptychopetalum olacoides;
Alcohol infusions of roots of Ptychopetalum olacoides Benth. (PO), known as Marapuama or Muirapuama, are used in the Brazilian Amazon as a ‘nerve tonic’. Over the years PO has been found increasingly in phytoformulations and regarded as a stimulant, claimed to enhance physical and mental performances. This study determined that a P. olacoides ethanol extract (30, 100 and 300mg/kg) decreased exploratory behaviour in the hole-board test, without interfering with locomotion or motor coordination (rota-rod test). The data are comparable to that obtained with pentylenetetrazol (40 mg/kg), suggesting an anxiogenic effect of P. olacoides. Copyright © 2002 John Wiley & Sons, Ltd.