Antioxidant activity of the methanol fraction of Pluchea indica root extract
Article first published online: 11 JUN 2002
Copyright © 2002 John Wiley & Sons, Ltd.
Volume 16, Issue 4, pages 331–335, June 2002
How to Cite
Sen, T., Dhara, A. K., Bhattacharjee, S., Pal, S. and Nag Chaudhuri, A. K. (2002), Antioxidant activity of the methanol fraction of Pluchea indica root extract. Phytother. Res., 16: 331–335. doi: 10.1002/ptr.892
- Issue published online: 11 JUN 2002
- Article first published online: 11 JUN 2002
- Manuscript Accepted: 11 JAN 2001
- Manuscript Received: 4 JUL 2000
- CSIR, New Delhi
- Pluchea indica;
- free radical;
- dual inhibitors
Studies were carried out to evaluate the influence of the methanol fraction of Pluchea indica Less root extract (PIRE), the dual inhibitors (BW 755C and phenidone) and vitamin on both in vivo and in vitro free radical-scavenging activities, CCl4-induced lipid peroxidation and the metabolism of arachidonic acid by lipoxygenase. PIRE produced significant antiinflammatory activity against glucose oxidase-induced paw oedema (in vivo), inhibited hydroxyl radical and superoxide generation, lysis of erythrocytes induced by hydrogen peroxide, CCl4-induced lipid peroxidation and also dioxygenase activity of lipoxygenase (both in the presence and absence of hydrogen peroxide). Significantly higher free radical-scavenging activity was observed with BW 755C and phenidone compared with PIRE. However, both BW 755C and phenidone stimulated hydroxyl radical generation compared with the observed inhibitory effects of PIRE and vitamin E. Copyright © 2002 John Wiley & Sons, Ltd.