Short Communication

The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats

  1. P. Mahendran,
  2. A. J. Vanisree,
  3. C. S. Shyamala Devi*

Article first published online: 23 JAN 2002

DOI: 10.1002/ptr.946

Issue

Phytotherapy Research

Phytotherapy Research

Volume 16, Issue 1, pages 80–83, February 2002

Additional Information

How to Cite

Mahendran, P., Vanisree, A. J. and Shyamala Devi, C. S. (2002), The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytotherapy Research, 16: 80–83. doi: 10.1002/ptr.946

Author Information

  1. Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India

*Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India

Publication History

  1. Issue published online: 23 JAN 2002
  2. Article first published online: 23 JAN 2002
  3. Manuscript Accepted: 28 FEB 2001
  4. Manuscript Received: 13 JUL 2000

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Keywords:

  • gastric ulcer;
  • Garcinia cambogia;
  • indomethacin;
  • antiulcer activity

Abstract

Garcinia cambogia extract is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. Oral pretreatment with Garcinia cambogia fruit extract (1 g/kg body wt/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20 mg/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent. Copyright © 2002 John Wiley & Sons, Ltd.

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