A theoretical study on binding orientations and quantitative structure–activity relationship (QSAR) of a novel series of alkene-3-quinolinecarbonitriles acting as Src inhibitors has been carried out by using the docking study and three-dimensional QSAR (3D-QSAR) analyses. The appropriate binding orientations and conformations of these compounds interacting with Src kinase were revealed by the docking studies, and the established 3D-QSAR models show significant statistical quality and satisfactory predictive ability, with high R2 values and q2 values: comparative molecular field analysis (CoMFA) model (q2 = 0.748, R2 = 0.972), comparative molecular similarity indices analysis (CoMSIA) model (q2 = 0.731, R2 = 0.987). The systemic external validation indicated that both CoMFA and CoMSIA models possessed high predictive powers with values of 0.818 and 0.892, values of 0.879 and 0.886, values of 0.874 and 0.874, values of 0.879 and 0.885, respectively. Several key structural features of the compounds responsible for inhibitory activity were discussed in detail. Based on these structural factors, eight new compounds with quite higher predicted Src-inhibitory activities have been designed and presented. We hope these theoretical results can offer some valuable references for the pharmaceutical molecular design as well as the action mechanism analysis. © 2012 Wiley Periodicals, Inc.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.