Cover Image, Volume 112, Issue 24


original image

This snapshot structure of the 1,2-distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) lipid bilayer containing gramicidin A (GA), a peptide that forms ion channels for monovalent cations, is presented by Hiroaki Saito and colleagues on page 3834. The water molecules and hydrogen atoms are hidden, and GA is drawn as a ribbon structure in the figure. The arrows indicate the lateral pressures in the polar and hydrophobic regions of the membrane. This molecular dynamics study reveals that the lateral pressure in the hydrophobic region compresses the GA in the membrane and changes the pore size of the channel, which influences the ion permeation through the GA channel.