Confirmation of pauling's theory that vitamin C improves immunity to infection
Article first published online: 18 JUN 2009
Copyright © 1978 John Wiley & Sons, Inc.
International Journal of Quantum Chemistry
Supplement: Proceedings of the International Symposium on Quantum Biology and Quantum Pharmacology
Volume 14, Issue Supplement S5, pages 15–20, 3/11 March 1978
How to Cite
Ramachandran, G. N. (1978), Confirmation of pauling's theory that vitamin C improves immunity to infection. Int. J. Quantum Chem., 14: 15–20. doi: 10.1002/qua.560140706
- Issue published online: 18 JUN 2009
- Article first published online: 18 JUN 2009
- Manuscript Received: 29 MAR 1978
It is pointed out that the complement Clq, associated with the immune response system, has a part containing about 80 residues with a collagen-like sequence, with Gly at every third location and having also a number of Hyp and Hyl residues in locations before Gly, and that it takes the triple-helical conformation characteristic of collagen. As with collagen biosynthesis, ascorbic acid is therefore expected to be required for its production. Also, collagen itself, in the extracellular matrix, is connected with the fibroblast surface protein (FSP), whose absence leads to cell proliferation, and whose addition leads to suppression of malignancy in tissue culture. All these show the great importance of vitamin C for resistance to diseases, and even to cancer, as has been widely advocated by Pauling.