Research Article

Automated multiple-layer spotting for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of synthetic polymers utilizing ink-jet printing technology

  1. Michael A. R. Meier,
  2. Berend-Jan de Gans,
  3. Antje M. J. van den Berg,
  4. Ulrich S. Schubert*

Article first published online: 17 SEP 2003

DOI: 10.1002/rcm.1195

Issue

Rapid Communications in Mass Spectrometry

Rapid Communications in Mass Spectrometry

Volume 17, Issue 20, pages 2349–2353, 30 October 2003

Additional Information

How to Cite

Meier, M. A. R., de Gans, B.-J., van den Berg, A. M. J. and Schubert, U. S. (2003), Automated multiple-layer spotting for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of synthetic polymers utilizing ink-jet printing technology. Rapid Communications in Mass Spectrometry, 17: 2349–2353. doi: 10.1002/rcm.1195

Author Information

  1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), P.O. Box 513, 5600 MB Eindhoven, The Netherlands

*Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Publication History

  1. Issue published online: 17 SEP 2003
  2. Article first published online: 17 SEP 2003
  3. Manuscript Revised: 19 AUG 2003
  4. Manuscript Accepted: 19 AUG 2003
  5. Manuscript Received: 11 JUL 2003

Funded by

  • The Dutch Polymer Institute
  • NWO

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Abstract

Recently, a new multiple-layer matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) sample spotting technique for poly(ethylene glycol), offering improved analysis possibilities, was described. In this contribution the application of ink-jet printing to automated, multiple-layer MALDI-TOFMS sample preparation of synthetic polymers is presented, allowing accurate deposition of matrix, additive and analyte solutions. The new sample preparation technique was evaluated for poly(ethylene glycol) as well as poly(methyl methacrylate) standards, and optimized settings for both synthetic polymers have been obtained. Copyright © 2003 John Wiley & Sons, Ltd.

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