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Revealing the mammalian lignan precursor secoisolariciresinol diglucoside in flax seed by ionspray mass spectrometry

Authors

  • Massimo Bambagiotti-Alberti,

    Corresponding author
    1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, via Gino Capponi 9, 50121, Florence, Italy
    • Dipartimento di Scienze Farmaceutiche, Università di Firenze, via Gino Capponi 9, 50121, Florence, Italy
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  • Silvia A. Coran,

    1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, via Gino Capponi 9, 50121, Florence, Italy
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  • Caterina Ghiara,

    1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, via Gino Capponi 9, 50121, Florence, Italy
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  • Valerio Giannellini,

    1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, via Gino Capponi 9, 50121, Florence, Italy
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  • Andrea Raffaelli,

    1. Centro di Studio del CNR per le Macromolecole Stereordinate ed Otticamente Attive, Dipartimento di Chimica e Chimica Industrial, Università di Pisa, via Risorgimento 35, 56126 Pisa, Italy
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  • Professor P. Traldi

    Sponsor Referee
    1. CNR Area di Ricerca di Padova, Padova, Italy
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Abstract

Ionspray mass spectrometry allowed the rapid detection and unambiguous identification of secoisolariciresinol diglucoside, an important mammalian lignan precursor occurring in flax seed. It was observed that this compound is embedded in a complex form, probably a complex glucoside of still undisclosed structure, among the polar solvent extractables of flax seed from which it could not be released as such without the intervention of alkaline methanolysis. Comparison of ionspray mass spectra of untreated and methanolysed flax-seed extracts confirmed methanolysis as the crucial step in setting up any further analytical or preparative procedure concerned with secoisolariciresinol diglucoside.

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