Long-distance stereochemical effects in deprotonated epimeric androstanediols in tandem mass spectrometry


  • Presented at the 11th Annual Meeting of the French Mass Spectrometry Society, held at Rouen, 20–22 September 1994.


Tandem mass spectrometry in negative-ion mode using ammonia as reagent gas has contributed to the differentiation of polyhydroxysteroids and to the study of stereochemical effects. The present study provides additional examples of sterochemical effects. A first observation of intramolecular OH catalysis yielding stereospecific H2O elimination is proposed.