Influence of different ionization conditions on the mass spectrometric behaviour of some fluorinated acyclic nucleoside analogs
Article first published online: 8 APR 2005
Copyright © 1995 John Wiley & Sons, Ltd.
Rapid Communications in Mass Spectrometry
Volume 9, Issue 12, pages 1127–1134, 1995
How to Cite
Favretto, D., Traldi, P., Bravo, P., Viani, F., Tamas, J., Czira, G. and Somogyi, A. (1995), Influence of different ionization conditions on the mass spectrometric behaviour of some fluorinated acyclic nucleoside analogs. Rapid Commun. Mass Spectrom., 9: 1127–1134. doi: 10.1002/rcm.1290091210
- Issue published online: 8 APR 2005
- Article first published online: 8 APR 2005
- Manuscript Accepted: 7 AUG 1995
- Manuscript Received: 5 AUG 1995
The behaviour of three fluorinated acyclic nucleoside analogs has been examined under different ionization conditions, i.e. by electron ionization, fast-atom bombardment and positive-ion chemical ionization using methane, isobutane and ammonia as reactant gases. The protonated molecules have been studied by collisional spectroscopy. In general, protonation takes place on the functional groups exhibiting a proton affinity higher than that of the reactant species but some discrepancies are present. They have been explained by the presence of quasi SHF structures implicating proton bridging between sulphur and fluorine atoms.