Analysis of unknown compounds in gentamicin bulk samples with liquid chromatography coupled with ion trap mass spectrometry

Authors

  • Bo Li,

    1. Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium
    Search for more papers by this author
  • Erwin Adams,

    1. Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium
    Search for more papers by this author
  • Ann Van Schepdael,

    Corresponding author
    1. Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium
    • Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium.
    Search for more papers by this author
  • Jos Hoogmartens

    1. Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium
    Search for more papers by this author

Abstract

Six unknown compounds present in bulk gentamicin samples have been identified by ion-pairing reversed-phase liquid chromatography coupled with ion trap mass spectrometry. The structures of these unknown compounds were deduced by comparison of their fragmentation patterns with those of the available related substances and gentamicin reference substances. Seven other unknown components were partially identified. Copyright © 2005 John Wiley & Sons, Ltd.

Ancillary