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Combined use of gas chromatography and selected ion flow tube mass spectrometry for absolute trace gas quantification

Authors

  • Jiří Kubišta,

    1. J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23 Prague 8, Czech Republic
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  • Patrik Španěl,

    1. J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23 Prague 8, Czech Republic
    2. Trans Spectra Limited, 9 The Elms, Porthill, Newcastle-under-Lyme ST5 8RP, UK
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  • Kseniya Dryahina,

    1. J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23 Prague 8, Czech Republic
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  • Clive Workman,

    1. Trans Spectra Limited, 9 The Elms, Porthill, Newcastle-under-Lyme ST5 8RP, UK
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  • David Smith

    Corresponding author
    1. Trans Spectra Limited, 9 The Elms, Porthill, Newcastle-under-Lyme ST5 8RP, UK
    2. Centre for Science and Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK
    • Centre for Science and Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK.
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Abstract

The value of the gas chromatography (GC) and selected ion flow tube mass spectrometry (SIFT-MS) combination for the analysis of trace gases is demonstrated by the quantification of acetone in air samples using the three precursor ions available to SIFT-MS, viz. H3O+, NO+ and Omath image, and by the separation of the isomers 1-propanol and 2-propanol, and their analysis using H3O+ precursor ions. It is shown that the GC/SIFT-MS combination allows for accurate trace gas quantification obviating the regular, time-consuming calibrations that are usually required for the more commonly used detectors of GC systems, and the positive identification of isomers in mixtures that is often challenging using SIFT-MS alone. Thus, the GC/SIFT-MS combination paves the way to more confident analyses of complex mixtures such as exhaled breath. Copyright © 2006 John Wiley & Sons, Ltd.

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