The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin
Article first published online: 3 APR 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Rapid Communications in Mass Spectrometry
Volume 20, Issue 9, pages 1447–1456, 15 May 2006
How to Cite
Williams, J. P., Patel, V. J., Holland, R. and Scrivens, J. H. (2006), The use of recently described ionisation techniques for the rapid analysis of some common drugs and samples of biological origin. Rapid Commun. Mass Spectrom., 20: 1447–1456. doi: 10.1002/rcm.2470
- Issue published online: 3 APR 2006
- Article first published online: 3 APR 2006
- Manuscript Accepted: 13 MAR 2006
- Manuscript Revised: 8 MAR 2006
- Manuscript Received: 5 FEB 2006
Three ionisation techniques that require no sample preparation or extraction prior to mass analysis have been used for the rapid analysis of pharmaceutical tablets and ointments. These methods were (i) the novel direct analysis in real time (DART), (ii) desorption electrospray ionisation (DESI), and (iii) desorption atmospheric pressure chemical ionisation (DAPCI). The performance of the three techniques was investigated for a number of common drugs. Significant differences between these approaches were observed. For compounds of moderate to low polarity DAPCI produced more effective ionisation. Accurate DESI and DAPCI tandem mass spectra were obtained and these greatly enhance the selectivity and information content of the experiment. The detection from human skin of the active ingredients from ointments is reported together with the detection of ibuprofen metabolites in human urine. Copyright © 2006 John Wiley & Sons, Ltd.