Research Article

Desorption electrospray ionization using an Orbitrap mass spectrometer: exact mass measurements on drugs and peptides

  1. Qizhi Hu,
  2. Nari Talaty,
  3. Robert J. Noll,
  4. R. Graham Cooks*

Article first published online: 19 OCT 2006

DOI: 10.1002/rcm.2757

Issue

Rapid Communications in Mass Spectrometry

Rapid Communications in Mass Spectrometry

Volume 20, Issue 22, pages 3403–3408, 30 November 2006

Additional Information

How to Cite

Hu, Q., Talaty, N., Noll, R. J. and Cooks, R. G. (2006), Desorption electrospray ionization using an Orbitrap mass spectrometer: exact mass measurements on drugs and peptides. Rapid Commun. Mass Spectrom., 20: 3403–3408. doi: 10.1002/rcm.2757

Author Information

  1. Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

*Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Publication History

  1. Issue published online: 19 OCT 2006
  2. Article first published online: 19 OCT 2006
  3. Manuscript Accepted: 23 SEP 2006
  4. Manuscript Revised: 22 SEP 2006
  5. Manuscript Received: 24 AUG 2006

Funded by

  • National Science Foundation. Grant Number: CHE-0216239
  • Office of Naval Research. Grant Number: N00014-02-0834
  • Thermo Electron Corporation

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (126K)

Abstract

Desorption electrospray ionization (DESI) is implemented on an Orbitrap mass spectrometer. The ion source is described and applications which utilize the high-resolution capabilities of the Orbitrap are emphasized, including the characterization of peptides and active ingredients in pharmaceutical tablets. Measurements are made in less than 1 s at a resolution of 60 000. The implications of the data for the mechanisms of DESI are discussed. Copyright © 2006 John Wiley & Sons, Ltd.

View Full Article (HTML) Get PDF (126K)