Detection of isocyanates and polychlorinated biphenyls using proton transfer reaction mass spectrometry
Article first published online: 6 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Rapid Communications in Mass Spectrometry
Volume 26, Issue 8, pages 983–989, 30 April 2012
How to Cite
Agarwal, B., Jürschik, S., Sulzer, P., Petersson, F., Jaksch, S., Jordan, A. and Märk, T. D. (2012), Detection of isocyanates and polychlorinated biphenyls using proton transfer reaction mass spectrometry. Rapid Commun. Mass Spectrom., 26: 983–989. doi: 10.1002/rcm.6173
- Issue published online: 28 FEB 2012
- Article first published online: 6 MAR 2012
- Manuscript Revised: 24 JAN 2012
- Manuscript Accepted: 24 JAN 2012
- Manuscript Received: 6 DEC 2011
- Marie Curie Industry-Academia Partnership and Pathways. Grant Number: Grant Agreement No. 218065
Isocyanates are highly reactive species widely used in industry. They can cause irritation of the eyes, trigger asthma, etc. Polychlorinated biphenyls (PCBs) were widely used in electrical equipments like capacitors and transformers in the last century and are still present in the environment today. PCBs are known to cause cancer and to affect the immune, reproductive, nervous and endocrine systems. Therefore, there is a need for a simple, rapid and reliable analytical method for the detection of traces of isocyanates and of PCBs.
The data presented in this paper were obtained using a proton transfer reaction (PTR) time-of-flight mass spectrometer and a high sensitivity PTR quadrupole mass spectrometer. We also utilized a recently developed direct aqueous injection (DAI) inlet system for proton transfer reaction mass spectrometry (PTR-MS) instruments that allows the analysis of trace compounds in liquids.
We detected four isocyanates in the headspace above small sample quantities and investigated their fragmentation pathways to obtain a fundamental understanding of the processes involved in proton transfer reactions and also to determine the best operating conditions of the PTR-MS instruments. In addition, nine PCBs were unambiguously identified via their exact mass and isotopic distribution and detected in different concentration levels via direct injection of the liquid.
Utilizing recent developments and improvements in PTR-MS, we can rapidly detect two important environmental pollutant compound classes (isocyanates and PCBs) at high accuracy and without any sample preparation. In this paper, we provide proof of the detection of traces of isocyanates and PCBs in air and also of PCBs in liquids. These results could be used for the development of a real-time monitoring device for industrial waste, polluted air or water quality surveillance. Copyright © 2012 John Wiley & Sons, Ltd.