Konstantinos Sousounis, Antony T. Athippozhy, S. Randal Voss and Panagiotis A. Tsonis
Axolotls lose the ability for lens regeneration two weeks after hatching. We used microarrays using RNA isolated from young and old iris. Electron transport chain, transcription, metabolism, and cell cycle gene ontologies, all important for lens regeneration, were enriched in the young iris. Cellular differentiation and innate immunity were uniquely expressed in old iris. We demonstrate age-related event s leading to the loss of lens regeneration ability in axolotls.