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Regeneration

Cover image for Vol. 1 Issue 3

June 2014

Volume 1, Issue 3

Pages i–iii, 1–57

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. REVIEW
    4. RESEARCH ARTICLES
    1. You have full text access to this Open Access content
      Issue Information (pages i–iii)

      Article first published online: 19 OCT 2014 | DOI: 10.1002/reg2.3

  2. REVIEW

    1. Top of page
    2. Issue Information
    3. REVIEW
    4. RESEARCH ARTICLES
    1. You have full text access to this OnlineOpen article
      Implication of two different regeneration systems in limb regeneration (pages 1–9)

      Aki Makanae, Kazumasa Mitogawa and Akira Satoh

      Article first published online: 29 AUG 2014 | DOI: 10.1002/reg2.16

      Thumbnail image of graphical abstract

      Typical phenotypes of accessory limbs.

      The ALM is a useful experimental tool for studying PD axis reconstitution.

  3. RESEARCH ARTICLES

    1. Top of page
    2. Issue Information
    3. REVIEW
    4. RESEARCH ARTICLES
    1. You have full text access to this OnlineOpen article
      Temporal and spatial analysis of enteric nervous system regeneration in the sea cucumber Holothuria glaberrima (pages 10–26)

      Karen Tossas, Sunny Qi-Huang, Eugenia Cuyar and Jose E. García-Arrarás

      Article first published online: 5 AUG 2014 | DOI: 10.1002/reg2.15

      Thumbnail image of graphical abstract

      Regeneration of the enteric nervous system was studied during the formation of a new intestine following evisceration in the sea cucumber H. glaberrima. Both extrinsic and intrinsic components of the enteric nervous system were shown to regenerate in a 1-2 month period.

    2. You have full text access to this OnlineOpen article
      Probability of regenerating a normal limb after bite injury in the Mexican axolotl (Ambystoma mexicanum) (pages 27–32)

      Sierra Thompson, Laura Muzinic, Christopher Muzinic, Matthew L. Niemiller and S. Randal Voss

      Article first published online: 27 AUG 2014 | DOI: 10.1002/reg2.17

      Thumbnail image of graphical abstract

      Multiple factors are thought to cause limb abnormalities in amphibian populations by altering processes of limb development and regeneration. We examined adult and juvenile axolotls (Ambystoma mexicanum) in the Ambystoma Genetic Stock Center (AGSC) for limb and digit abnormalities to estimate the probability of normal regeneration after bite injury. We infer that only 43% of AGSC larvae will present four anatomically normal looking adult limbs after incurring a bite injury. Our results show regeneration of normal limb anatomy to be less than perfect after bite injury.

    3. You have full text access to this OnlineOpen article
      Angiogenesis is inhibitory for mammalian digit regeneration (pages 33–46)

      Ling Yu, Mingquan Yan, Jennifer Simkin, Paulina D. Ketcham, Eric Leininger, Manjong Han and Ken Muneoka

      Article first published online: 12 OCT 2014 | DOI: 10.1002/reg2.24

      Thumbnail image of graphical abstract

      The digit regeneration blastema is avascular and expresses the anti-angiogenic factor, PEDF. Precocious angiogenesis induced by VEGF is inhibitory for a regeneration response.

    4. You have full text access to this OnlineOpen article
      Plasticity for axolotl lens regeneration is associated with age-related changes in gene expression (pages 47–57)

      Konstantinos Sousounis, Antony T. Athippozhy, S. Randal Voss and Panagiotis A. Tsonis

      Article first published online: 12 OCT 2014 | DOI: 10.1002/reg2.25

      Thumbnail image of graphical abstract

      Axolotls lose the ability for lens regeneration two weeks after hatching. We used microarrays using RNA isolated from young and old iris. Electron transport chain, transcription, metabolism, and cell cycle gene ontologies, all important for lens regeneration, were enriched in the young iris. Cellular differentiation and innate immunity were uniquely expressed in old iris. We demonstrate age-related event s leading to the loss of lens regeneration ability in axolotls.

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